1-(4-chlorobenzyl)-1H-pyrazol-3-amine → 5-[1-(4-Chloro-benzyl)-1H-pyrazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

HRID 2063683Notes

Reaction equation

HRID 2063683 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[Cl:16][C:17]1[CH:29]=[CH:28][C:20]([CH2:21][N:22]2[CH:26]=[CH:25][C:24]([NH2:27])=[N:23]2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:29]=[CH:28][C:20]([CH2:21][N:22]2[CH:26]=[CH:25][C:24]([NH:27][C:2]3[CH:3]=[CH:4][C:5]([N:10]4[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]4)=[C:6]([CH:9]=3)[C:7]#[N:8])=[N:23]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 6736901-(4-chlorobenzyl)-1H-pyrazol-3-amineHCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile

Product 1

HCID 461867755-[1-(4-Chloro-benzyl)-1H-pyrazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

Procedure

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(4-chloro-benzyl)-1H-pyrazol-3-yl amine. The title compound was obtained as a light yellow solid (Yield=28%). MS ISP (m/e): 389.2 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-ab797b6c84a04ef1a6b3d78466476f79
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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