HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile → 5-[3-Cyano-4-(4-methyl-imidazol-1-yl)-phenylamino]-2-(3,4,5-trifluoro-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile | HCID 66961517 | — |
| Reactant | HCID 67365405 | HCID 67365405 | — |
| Product | 5-[3-Cyano-4-(4-methyl-imidazol-1-yl)-phenylamino]-2-(3,4,5-trifluoro-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester | HCID 46216419 | — |
Reaction Steps
Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 5-amino-2-(3,4,5-trifluoro-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester. The title compound was obtained as a colorless solid (Yield=15%). MS ISP (m/e): 467.2 (100) [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288403B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-e231c6379603436885f1f230b6482815 |
| Source note | uspto-grants-2012_10 |