1-(4-Fluorobenzyl)-1H-pyrazol-3-amine → HCID 46216421, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(4-bromo-2-methoxy-phenyl)-4-methyl-1H-imidazole (WO2009076352, Example 1; 50 mg, 0.19 mmol), 1-(4-fluoro-benzyl)-1H-pyrazol-3-ylamine (45 mg, 0.40 mmol), sodium phenoxide (35 mg, 0.57 mmol), tris(dibenzylideneacetone)dipalladium chloroform complex (3 mg, 0.003 mmol) and 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene=Xanthphos (7 mg, 0.012 mmol) in dioxane (2 ml) was heated under an argon atmosphere in the microwave to 130° C. for 15 min. The mixture was diluted with water, extracted with dichloromethane and the product purified by chromatography on silica gel using dichloromethane/methanol as eluent. The title compound was obtained as a light yellow solid (Yield=42%). MS ISP (m/e): 378.4 (100) [(M+H)+].

Provenance & Evidence