1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole → HCID 46216604, compound

HRID 2063699Notes

Reaction equation

HRID 2063699 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[CH3:16][O:17][C:18]([C:20]1[N:21]([CH2:26][C:27]2[CH:32]=[C:31]([F:33])[C:30]([F:34])=[C:29]([F:35])[CH:28]=2)[N:22]=[C:23]([NH2:25])[CH:24]=1)=[O:19]>>[CH3:16][O:17][C:18]([C:20]1[N:21]([CH2:26][C:27]2[CH:32]=[C:31]([F:33])[C:30]([F:34])=[C:29]([F:35])[CH:28]=2)[N:22]=[C:23]([NH:25][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]3)=[C:4]([O:14][CH3:15])[CH:3]=2)[CH:24]=1)=[O:19]

Participants

3

Reactant 2

HCID 534156611-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazoleHCID 67365405HCID 67365405, compound

Product 1

HCID 46216604HCID 46216604, compound

Procedure

Prepared in analogy to example 1b) starting with 1-(4-bromo-2-methoxy-phenyl)-4-methyl-1H-imidazole (WO2009076352) and 5-amino-2-(3,4,5-trifluoro-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester from example 39b). The title compound was obtained as a yellowish solid (Yield=34%). MS ISP (m/e): 472.1 (100) [(M+H)+].

Workup

  1. customPrepared in analogy to example 1b)

Sources & evidence

ORD record
ord-8009bc635c2549f3a405dbf4bf2df38e
Source dataset
uspto-grants-2012_10
Patent number
US08288403B2

Reaction notes

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