Methanesulfonyl chloride → HCID 67085429, compound

Participants

Reaction Steps

(S)-2-(1-(4-bromophenyl)pyrrolidin-2-yl)acetonitrile: To a solution of 20A (2 g, 7.81 mmol) in methylene chloride (16 mL) at 0° C. was added TEA (2.177 mL, 15.62 mmol), and methanesulfonyl chloride (0.913 mL, 11.71 mmol). After 1 h, the reaction mixture was diluted with water and methylene chloride. The layers were extracted, and the organic layer was dried and concentrated to give 2.6 g of 1-(4-bromophenyl)-2-(methylsulfonylmethyl)pyrrolidine (8.17 mmol, 105% yield) as a brown oil that was used directly in the next step. To a solution of 1-(4-bromophenyl)-2-(methylsulfonylmethyl)pyrrolidine (2.6 g, 8.17 mmol) in DMSO (16 mL) was added NaCN (1.531 g, 31.2 mmol) and the resultant mixture was stirred at 50° C. overnight. The reaction mixture was diluted with EtOAc and water. The layers were extracted, and the organic layer was washed successively with water and brine. The organic layer was dried and concentrated, and the resulting material was purified via silica gel chromatography to give 20B (brown oil, 2.1 g, 7.92 mmol, 101% yield). Anal Calc'd for C12H13BrN2 264.03. found [M+H]=264.9, 266.9.

Provenance & Evidence