Potassium Carbonate → HCID 58218641, compound

Participants

Reaction Conditions

Reaction Steps

(13A, 24.93 mg, 0.10 mmol) in DMF (1 mL) was added 1-(bromomethyl)-3-methylbenzene (19.6 mg, 0.105 mmol) following with K2CO3 (28 mg, 0.200 mmol). The reaction was stirred at 80° C. for 18 h. Volatile solvents were evaporated and the residue was diluted with 1:1 methanol:dioxane (0.35 0 mL, 0.152 M). To this solution was added 1M NaOH (0.350 mL) and the reaction was stirred at rt for 18 h. Volatile solvents were evaporated and the residue was diluted in DMF (1.250 mL) and distilled water (0.250 mL) and purified using Waters Sunfire (19×100 mm, 5 nm C18, 5:95 CH3CN:Water, 0.05% TFA) to yield Example 69. LC-MS Anal. Calc'd for C20H23NO3 325.40. found [M+H] 326.23.

Provenance & Evidence