Hydrogen iodide → HCID 51347406, compound

Participants

Reaction Steps

Example 89 (pale yellow oil, 0.017 g, 0.047 mmol, 36% yield) was prepared from ethyl 2-(1-(4-(4-chloro-2-methylbenzoyl)phenyl)pyrrolidin-2-yl)acetate (88E) following the procedure of 86H. LC-MS Anal. Calc'd for C20H20ClNO3 357. found [M+H] 358. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.4 (1H, brs), 7.55 (2H, d, J=8.8 Hz), 7.43 (1H, d, J=1.2 Hz), 7.36 (1H, dd, J=1.2, 8.0 Hz), 7.24 (1H, d, J=8.0 Hz), 6.62 (2H, d, J=8.8 Hz), 4.17 (1H, m), 3.47 (1H, m), 3.22 (1H, m), 2.58 (1H, m), 2.30 (1H, m), 2.17 (3H, s), 2.06 (3H, m), 1.99 (1H, m). Analytical HPLC: RT=18.7 min, HI: 92.9%.

Provenance & Evidence