Ethyl vinyl ether → 4-[1-(1-Ethoxy-ethoxy)-2-phenylethyl]cyclohexanone

Participants

Reaction Steps

Ethyl vinyl ether (998 mg, 1.32 ml, 13.8 mmol) and pyridinium tosylate (44 mg, 0.17 mmol) were added to a solution of 4-(1-hydroxy-2-phenylethyl)cyclohexanone (2.52 g, 11.5 mmol) in anhydrous methylene chloride (50 ml) and the mixture was stirred at room temperature overnight. Methylene chloride (20 ml) was added to the mixture and the mixture was washed with water, 5% sodium bicarbonate solution and sodium chloride solution (50 ml of each). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

Provenance & Evidence