Hydrochloric Acid → HCID 69809375, compound

Participants

Reaction Steps

40% aqueous dimethylamine solution (596 μl, 4.73 mmol) was added to a mixture of 4 M hydrochloric acid (256 μl) and methanol (153 μl), while cooling with ice. A solution of the product from stage 6 (557 mg, 0.98 mmol) in methanol (3 ml) and tetrahydrofuran (3 ml) was added to the mixture. Potassium cyanide (153 mg, 2.36 mmol) and water (2 ml) were then added. The suspension was stirred at room temperature overnight and thereafter diluted with water (20 ml). The mixture was extracted with diethyl ether (5×20 ml). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

Provenance & Evidence