反应详情

A solution of 8-oxiranyl-1,4-dioxaspiro[4.5]decane (1.41 g, 7.66 mmol), isoindoline (1.00 g, 8.43 mmol) and calcium trifluoromethanesulfonate (1.29 g, 3.8 mmol) in anhydrous acetonitrile (60 ml) was stirred at room temperature overnight. The solvent was then concentrated in vacuo. The residue was taken up in ethyl acetate (50 ml) and the solution was washed with 25% potassium carbonate solution (3×50 ml). The aqueous phase was extracted with ethyl acetate (3×40 ml) and the combined organic phases were dried with sodium sulfate and concentrated in vacuo.

1. concentrationThe solvent was then concentrated in vacuo
2. washthe solution was washed with 25% potassium carbonate solution (3×50 ml)
3. extractionThe aqueous phase was extracted with ethyl acetate (3×40 ml)
4. dry with materialthe combined organic phases were dried with sodium sulfate
5. concentrationconcentrated in vacuo