HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one → 3-(4,5-Dihydro-2-oxa-1,3,7,9-tetraaza-cyclopenta[a]naphthalen-8-ylamino)-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Dimethylaminomethylene-6,7-dihydro-5H-benzo[1,2,5]oxadiazol-4-one | HCID 67405521 | — |
| Reactant | HCID 178418735 | HCID 178418735 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(4,5-Dihydro-2-oxa-1,3,7,9-tetraaza-cyclopenta[a]naphthalen-8-ylamino)-phenol | HCID 11403271 | — |
Reaction Steps
The DMF solution of 5-dimethylaminomethylene-6,7-dihydro-5 H-benzo[1,2,5]oxadiazol-4-one 0.1 g (0.00052 mol) and 3 equivalents of N-(3-hydroxy-phenyl)-guanidine was stirred at 110° C. for overnight, the final product was purified by directly injecting the DMF reaction solution into prep HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288400B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ee62e65580274e2b8cf252ecee6d6d75 |
| Source note | uspto-grants-2012_10 |