HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodotoluene → 1-(4-Methylphenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodotoluene | HCID 12207 | — |
| Reactant | 1-(2,4,6,7-Tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 66759810 | — |
| Product | 1-(4-Methylphenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 59485002 | 33% |
Reaction Steps
By using 1-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (700 mg, 2.69 mmol) synthesized in Reference example 56 and 4-iodotoluene (1.76 g, 8.08 mmol), the reaction was carried out in the same manner as Example 23 to synthesize the title compound 310 mg (yield 33%). Melting point was 150 to 151° C. (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288390B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-a4c4c197b1b94f368e8f8411b28cc2b5 |
| Source note | uspto-grants-2012_10 |