HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dibromobenzene → 1-(4-Bromophenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dibromobenzene | HCID 7804 | — |
| Reactant | 1-(2,4,6,7-Tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 66759810 | — |
| Product | 1-(4-Bromophenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 59485039 | 55.4% |
Reaction Steps
By using 1-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (2.60 g, 10.0 mmol) synthesized in Reference example 56 and 1,4-dibromobenzene (7.08 g, 30 mmol), the reaction was carried out in the same manner as Example 23 to synthesize the title compound 2.3 g (yield 55%). Melting point was 202 to 204° C. (hexane-ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288390B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-d00c0ccd332e4eee96b520b9bbfe2395 |
| Source note | uspto-grants-2012_10 |