HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromophenetole → 1-(4-Ethoxyphenyl)-4-(7-ethoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromophenetole | HCID 68523 | — |
| Reactant | 1-(7-Ethoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 66759671 | — |
| Product | 1-(4-Ethoxyphenyl)-4-(7-ethoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 59485011 | 65% |
Reaction Steps
By using 1-(7-ethoxy-2,4,6-trimethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (580 mg, 2.0 mmol) synthesized in Reference example 89 and 1-bromo-4-ethoxybenzene (804 mg, 4.0 mmol), the reaction was carried out in the same manner as Example 23 to synthesize the title compound 532 mg (yield 65%). Melting point was 121 to 122° C. (ethanol-water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288390B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-b88bd2b1230b492abb35762a86396ab7 |
| Source note | uspto-grants-2012_10 |