Methyl iodide → HCID 68783444, compound

Participants

Reaction Steps

The tert-butyl 4-(1H-benzimidazol-2-yl)piperidine-1-carboxylate (50.0 mg, 0.166 mmol) was dissolved in 2 mL of acetone with freshly ground potassium hydroxide (46.4 mg, 0.830 mmol). The mixture was stirred for 10 minutes at ambient temperature, and then methyl iodide (11.4 μL, 0.183 mmol) was added. After 10 minutes, the reaction was quenched by adding saturated aqueous ammonium chloride solution (10 mL). The sample was diluted with EtOAc (3×30 mL), washed with water (2×20 mL), and washed with brine (2×20 mL). The organic layer was dried over sodium sulfate, filtered, concentrated to give tert-butyl 4-(1-methyl-1H-benzimidazol-2-yl)piperidine-1-carboxylate.

Provenance & Evidence