HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 1-(5-Phenyl-pentyl)-3-(2-trifluoromethyl-phenylsulfanyl)-quinolinium iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Benzene, (5-iodopentyl)- | HCID 561241 | — |
| Reactant | 3-(2-Trifluoromethyl-phenylsulfanyl)-quinoline | HCID 53231687 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | 1-(5-Phenyl-pentyl)-3-(2-trifluoromethyl-phenylsulfanyl)-quinolinium iodide | HCID 53232042 | 90.1% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 3-(2-trifluoromethyl-phenylsulfanyl)-quinoline (370 mg, 1.21 mmol), (5-iodo-pentyl)-benzene (520 mg, 1.9 mmol) in tetramethylene sulfone (1 mL) was sealed in a tube and heated at 100° C. for 12 h. Ether (10 mL) was added resulting in a solid product. The product was crystallized from MeOH-Et2O to yield 1-(5-phenyl-pentyl)-3-(2-trifluoromethyl-phenylsulfanyl)-quinolinium iodide (632 mg, 90%). Mp 227-229° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288410B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-70f5952758d34c2b8226606113ee0129 |
| Source note | uspto-grants-2012_10 |