反应详情

温度

110 °C

A mixture of phenylquinolin-3-yl-amine (100 mg, 0.46 mmol) in toluene (2 ml) and 5-iodopentylbenzene (373 mg, 1.36 mmol) in sealed pressure tube was stirred at 110° C. for 24 hours. The reaction mixture was allowed to cool to room temperature, diluted with Et2O (15 ml), and the resulting precipitate was filtered and washed with Et2O (3×20 ml). The crude product was purified by column chromatography using MeOH/Et2O as eluent. The pure product was an orange solid (75 mg). Mp: 140-141° C.

1. temperatureto cool to room temperature
2. filtrationthe resulting precipitate was filtered
3. washwashed with Et2O (3×20 ml)
4. customThe crude product was purified by column chromatography