Methyl iodide → HCID 67980256, compound

HRID 2063939Notes

Reaction equation

HRID 2063939 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[C:9]3[CH:10]=[N:11][C:12]4[C:17]([C:18]=3[C:4]=2[CH:3]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4.[CH3:30][I:31]>C1(C)C=CC=CC=1.CCOCC>[I-:31].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH:24]3[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]3)[C:9]3[CH:10]=[N+:11]([CH3:30])[C:12]4[C:17]([C:18]=3[C:4]=2[CH:3]=1)=[CH:16][CH:15]=[CH:14][CH:13]=4

Participants

5

Reactant 2

HCID 6328Methyl iodideHCID 67980273HCID 67980273, compound

Product 1

HCID 67980256HCID 67980256, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 10-chloro-7-(5-cyclohexyl-pentyl)-7H-indolo[2,3-c]-quinoline (65 mg) in toluene (3 ml) and CH3I (0.3 mL) was stirred in a sealed pressure tube at 110° C. for 24 hours. The reaction mixture was allowed to cool to room temperature, diluted with Et2O (15 ml) and the resulting precipitate was filtered and washed with Et2O (3×20 ml) to yield the pure angular product as an orange solid (50 mg). Mp 246-248° C.

Workup

  1. temperatureto cool to room temperature
  2. filtrationthe resulting precipitate was filtered
  3. washwashed with Et2O (3×20 ml)

Sources & evidence

ORD record
ord-061a8af88e3441e3aab8a478c159ad5e
Source dataset
uspto-grants-2012_10
Patent number
US08288410B2

Reaction notes

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