HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-O-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine → (R)-5-(4-Bromo-2-fluorophenylamino)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)imidazo[1,5-a]pyrazine-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-O-((2,2-Dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine | HCID 11298047 | — |
| Reactant | 5-(4-Bromo-2-fluorophenylamino)-N-(2-(vinyloxy)ethoxy)-imidazo[1,5-a]pyrazine-6-carboxamide | HCID 59140182 | — |
| Product | (R)-5-(4-Bromo-2-fluorophenylamino)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)imidazo[1,5-a]pyrazine-6-carboxamide | HCID 59140128 | — |
Reaction Steps
The desired compound was prepared in an analogous fashion to 5-(4-bromo-2-fluorophenylamino)-N-(2-(vinyloxy)ethoxy)-imidazo[1,5-a]pyrazine-6-carboxamide, using (R)—O-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)hydroxylamine as the starting material. LCMS (method D1): RT=0.954 min, [M+H]+=480/482.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288408B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-5bb856fecacd49118be47d1acb285cda |
| Source note | uspto-grants-2012_10 |