1-Carbethoxy-4-(5-chloro-2-nitroanilino)-piperidine → Domperidone Impurity 12

関与物質

反応手順

A suspension of D5 (15.0 g, 45 mmol) and 5% Pt/C (1.5 g) in methanol (500 mL) in an autoclave (1000 mL) was put under an atmosphere of hydrogen (˜40 atm). The mixture was stirred at room temperature for 3 hours and then filtered through a pad of celite. The filtrate was concentrated under reduced pressure to give the title compound (13.5 g, 100% yield) as a dark brown solid that was used without further purification. (Rf: 0.3 (ethyl acetate/hexane 7:8))

情報源と証拠