Ethyl Acetate → HCID 57423913, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tris(dibenzylideneacetone)dipalladium (0) (0.14 g), 1,1′-bis(diphenylphosphino)ferrocene (0.07 g), sodium tert-butoxide (0.4 g) in 1,4-dioxane (10 mL) was stirred under an atmosphere of argon for 10 minutes. 1,1-dimethylethyl 4-[({[2-bromo-4-(1-methylethyl)phenyl]amino}carbonyl)amino]-1-piperidinecarboxylate D33 (2.7 g) was added and the mixture was heated to 90° C. The mixture was stirred at this temperature overnight. The mixture was poured into ethyl acetate which was washed with dilute sodium bicarbonate, brine and dried over sodium sulphate. The solvent was removed and the residue was chromatographed on silica gel eluted with ethyl acetate/hexane 0-50% to give the title compound as a solid. (0.723 g)

Provenance & Evidence