Acetone Cyanohydrin → HCID 59863012, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-piperidin-4-yl-6-(trifluoromethoxy)-1,3-dihydro-2H-benzimidazol-2-one (D32, 301 mg), 2-hydroxy-2-methylpropanenitrile, (160 mg), tetrahydro-4H-pyran-4-one (200 mg) magnesium sulphate (600 mg) and N,N-dimethylacetamide (1 ml) were stirred at 60° C. under a slow stream of argon overnight. The resulting white paste was partitioned between dichloromethane and water and sonicated. The dichloromethane layer was separated, dried by passing through a 3 g hydromatrix cartridge. (Large proportion of the material was lost due to spillage). The solvent was removed and the title compound was obtained as a white solid from ether. Yield 62 mg. M+ 411.

Provenance & Evidence