Potassium Cyanide → HCID 57423915, compound

Participants

Reaction Steps

6-Methyl-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one hydrochloride salt (D14b, 1 g, 3.74 mmol) was dissolved in water (20 ml) and the pH of the solution was adjusted between 3 and 4. Tetrahydro-4H-pyran-4-one (0.455 g, 4.55 mmol) was added and the mixture stirred at room temperature for 10 minutes, then KCN (0.365 g, 5.61 mmol) was added and the solution was stirred at room temperature for 24 h. A white solid was collected by filtration, washed with cold water and dried in the oven (mixture 9:1 nitrile compound/starting material). This mixture was used without further purification (0.8 g, 2.35 mmol, 63% yield). MH+=341 and 342.

Provenance & Evidence