Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromoaniline | HCID 11562 | — |
| Reactant | Benzonitrile, 4-chloro-3-nitro- | HCID 13655 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 67152351 | HCID 67152351 | 66.5% |
Reaction Steps
To a mixture of 4-chloro-3-nitrobenzonitrile (A) (5 g, 27.4 mmol) and diisopropyl-ethylamine (4.24 g, 32 mmol) in NMP (40 mL) was added 3-bromoaniline (B) (4.71 g, 27.4 mmol) and the reaction mixture was stirred at 80° C. for 6 h. The reaction mixture was cooled to RT and diluted with water. The solid was filtered off, washed several times with water to remove excess 3-bromoaniline, dried under vacuum to give compound C (5.8 g, 66%) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08288418B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-03473e27d4ef454389d1453f2fe7dd91 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
