Hydrazine hydrate (1:1) → HCID 59850166, compound

Participants

Reaction Conditions

Reaction Steps

1,1-Dimethylethyl 4-[(5-chloro-4-fluoro-2-nitrophenyl)amino]-piperidinecarboxylate (D2) (0.91 mmol, 340 mg) was dissolved in ethanol (20 ml) and an aqueous suspension of Raney-Nickel (1 ml) was added at room temperature; the mixture was heated to 40° C. and hydrazine monohydrate (15 eq., 13.7 mmol, 0.424 ml) was added over 20 min at 40° C. The reaction mixture was then cooled to room temperature, filtered through celite and the solvent was evaporated to yield the title compound, which was purified by chromatography, complete conversion, 312 mg, M+−H=342.

Provenance & Evidence