反应详情

Iodine monochloride (1.5 g) was added in one portion to a mixture of 3-chloro-4-trifluoromethylaniline (1.7 g), sodium acetate trihydrate (2.2 g), and acetic acid (10 ml) at room temperature. After 30 min aqueous sodium bicarbonate/sodium sulfite was added and the mixture extracted with diethyl ether. The organic phase was dried over Na2SO4, filtered and evaporated. The residue was purified by chromatography (ethyl acetate-hexane) to afford the title compound, 2.2 g.

1. extractionthe mixture extracted with diethyl ether
2. dry with materialThe organic phase was dried over Na2SO4
3. filtrationfiltered
4. customevaporated
5. customThe residue was purified by chromatography (ethyl acetate-hexane)