Potassium Nitrate → 1-Bromo-4-fluoro-2-methyl-5-nitrobenzene

Participants

Reaction Conditions

Reaction Steps

1-Bromo-4-fluoro-2-methylbenzene (10 mmol, 1.89 g) was dissolved in concentrated H2SO4 (sp. gr 1.18) (10 mL) under argon and the mixture cooled to 0° C. KNO3 (10 mmol, 1.01 g) was added portion wise, maintaining the temperature around 0° C. The mixture was then allowed to stir at between 0° C. and 20° C. for 2 h. The reaction mixture was poured into ice and the product extracted with ether (×2). The organic layers were combined, dried (MgSO4) and the solvent removed under reduced pressure to yield the product as an oil (9.4 mmol, 2.2 g, 94%)

Provenance & Evidence