Trifluoroacetic acid → HCID 59850173, compound

Participants

Reaction Steps

1,1-Dimethylethyl 4-(5-bromo-6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D36) (1.32 mmol, 541 mg) was dissolved in dichloromethane (5 mL), trifluoroacetic acid (5 mL) added and the mixture stirred under argon at room temperature for 1 h. The reaction mixture was concentrated under reduced pressure, Na2CO3 (10% aqueous solution) added and the product extracted with ethyl acetate (×3). The organic layers were combined, dried (MgSO4) and the solvent removed under reduced pressure to afford the product as a yellow solid (1.16 mmol, 359 mg, 88%)

Provenance & Evidence