Hydrazine hydrate (1:1) → HCID 59850204, compound

Participants

Reaction Conditions

Reaction Steps

N-(4,5-Dichloro-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine (D38) (320 mg) was dissolved in ethanol (20 ml) and Raney nickel (50% aqueous suspension, 0.5 ml) was added at room temperature; the mixture was heated to 40° C. and hydrazine monohydrate (0.4 ml) was added over 20 min. After 30 min more, the reaction mixture was cooled to room temperature, filtered through Celite and the solvent was evaporated. Chromatography on silica gel eluting with methanol-dichloromethane mixtures yielded the title compound, 150 mg.

Provenance & Evidence