HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Chloro-4-fluoro-2-methoxy-5-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-fluoro-4-nitrophenol | HCID 59685329 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-Chloro-4-fluoro-2-methoxy-5-nitrobenzene | HCID 59850196 | — |
Reaction Steps
A mixture of 2-chloro-4-nitro-5-fluorophenol (D41) (450 mg), potassium carbonate (600 mg), iodomethane (1 ml), and dimethylformamide (5 ml) stirred overnight at room temperature then diethyl ether added and the solution washed with water then dried over MgSO4, filtered and evaporated The product was crystallised from hexane to yield the title compound, 350 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288412B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-9d9ac6ba16b54bf49462fd50602d0c42 |
| Source note | uspto-grants-2012_10 |