Hydrazine hydrate (1:1) → HCID 59850151, compound

Participants

Reaction Conditions

Reaction Steps

1,1-Dimethylethyl 4-[(4-fluoro5-bromo-2-nitrophenyl)amino]-piperidinecarboxylate (D43) (0.91 g, 2.2 mmole) was suspended in ethanol (25 ml) and Raney nickel (50% aqueous suspension, 100 mg) was added at room temperature; the mixture was heated to 45° C. and hydrazine monohydrate (3.0 ml) was added over 10 min. After 1 hr more, the reaction mixture was cooled to room temperature, filtered through Celite and the solvent was evaporated to yield the title compound as an orange brown gum, 0.83 g, 98%. LC/MS—96% m/e 388/390 (M+H).

Provenance & Evidence