Bis-(1H-imidazol-2-YL)-methanone → HCID 59850132, compound

Participants

Reaction Steps

1,1-Dimethylethyl 4-[(2-amino-4-fluoro-5-bromophenyl)amino]-1-piperidinecarboxylate (D44) (0.83 g, 2.1 mmole) was dissolved in anhydrous tetrahydrofuran (20 ml) and carbonyl diimidazole (0.51 g, 3.2 mmole) was added in portions over 15 minutes. The mixture was stirred at rt for 1 hr and the at reflux temperature for 18 hrs. The cooled mixture was concentrated to dryness under vacuum and the residue purified by silica gel chromatography eluting with 15-100% ethyl acetate in n-pentane to afford the title compound as a buff solid, 0.54 g, 51% LC/MS—85% m/e 412/414 (MH−).

Provenance & Evidence