HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1,1-Dimethylethyl 4-[(5-methoxy-4-chloro-2-nitrophenyl)amino]-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| Reactant | 1-Chloro-4-fluoro-2-methoxy-5-nitrobenzene | HCID 59850196 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Diisopropylethylamine | HCID 81531 | — |
| Product | 1,1-Dimethylethyl 4-[(5-methoxy-4-chloro-2-nitrophenyl)amino]-piperidinecarboxylate | HCID 59850143 | — |
Reaction Steps
2-Chloro-4-nitro-5-fluoroanisole (D42) (300 mg) was dissolved in dry dimethylformamide (3 ml) and diisopropylethylamine (0.3 ml), and 1,1-dimethylethyl 4-amino-1-piperidinecarboxylate (330 mg) were added at room temperature. The mixture was stirred for 3 h, then water and ethyl acetate added. The organic layer was dried over MgSO4, filtered and evaporated, and the residue was crystallised from diethyl ether to afford the title compound, 400 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288412B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-8c1e4dff41b747eba27e6bc4dfa2a307 |
| Source note | uspto-grants-2012_10 |