Hydrazine hydrate (1:1) → HCID 59850188, compound

Participants

Reaction Conditions

Reaction Steps

N-(5-Chloro-4-trifluoromethyl-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine (D51) (0.64 g, 1.57 mmole) was dissolved in ethanol (25 ml) and Raney nickel (50% aqueous suspension, 100 mg) was added at room temperature; the mixture was heated to 60° C. and hydrazine monohydrate (0.8 ml) was added over 30 min. After 2 hr more, the reaction mixture was cooled to room temperature, filtered through Celite and the solvent was evaporated to dryness. The residue was purified by silica gel chromatography eluting with 2 to 20% methanol in dichloromethane to yield the title compound as a cream solid, 0.34 g, 58%. MH+=378 and 380.

Provenance & Evidence