反应详情

温度

0 °C

4-Fluoro-2-methyl-1-(trifluoromethyl)benzene (5.6 mmol, 1 g) was dissolved in concentrated sulphuric acid (7 ml) and cooled to 0° C.; KNO3 (1 eq., 5.6 mmol, 566 mg) was added at to 0° C. in one pot and the mixture was stirred at to 0° C. for 4 hours. The crude mixture was poured onto ice and extracted with ethyl acetate; the organics were combined dried over Na2SO4, filtered and the solvent was evaporated to afford the title compound, 1.1 g, 88%.

1. extractionextracted with ethyl acetate
2. dry with materialthe organics were combined dried over Na2SO4
3. filtrationfiltered
4. customthe solvent was evaporated