Potassium Nitrate → 1-Fluoro-5-methyl-2-nitro-4-(trifluoromethyl)benzene
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[C:4]([CH3:12])[CH:3]=1.[N+:13]([O-])([O-:15])=[O:14].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([C:8]([F:9])([F:10])[F:11])=[CH:6][C:7]=1[N+:13]([O-:15])=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
4-Fluoro-2-methyl-1-(trifluoromethyl)benzene (5.6 mmol, 1 g) was dissolved in concentrated sulphuric acid (7 ml) and cooled to 0° C.; KNO3 (1 eq., 5.6 mmol, 566 mg) was added at to 0° C. in one pot and the mixture was stirred at to 0° C. for 4 hours. The crude mixture was poured onto ice and extracted with ethyl acetate; the organics were combined dried over Na2SO4, filtered and the solvent was evaporated to afford the title compound, 1.1 g, 88%.
Workup
- extractionextracted with ethyl acetate
- dry with materialthe organics were combined dried over Na2SO4
- filtrationfiltered
- customthe solvent was evaporated
Sources & evidence
- ORD record
- ord-61bdcc90da194ea1b1cd8b3b115f62be
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288412B2
Reaction notes
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