反应详情

A solution of 1,1-dimethylethyl 4-[6-bromo-2-oxo-5-(trifluoromethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-piperidinecarboxylate (D68, 0.95 g, 2.0 mmol) in diethyl ether (50 ml) and methanol (10 ml) was treated at room temperature with 1M HCl/diethyl ether (10 ml, 10 mmol) and stirred for 20 hrs. The precipitate was filtered off, washed with diethyl ether and dried to afford the title compound as a beige solid (0.71 g, 87%).

1. filtrationThe precipitate was filtered off
2. washwashed with diethyl ether
3. customdried