Ammonium formate → (2-Amino-5-ethyl-4-fluorophenyl)-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]amine

Beteiligte Stoffe

Reaktionsschritte

A mixture of N-(5-ethenyl-4-fluoro-2-nitrophenyl)-1-(tetrahydro-2H-pyran-4-yl)-4-piperidinamine (D79, 300 mg, 0.86 mmol) and ammonium formate (536 mg, 8.6 mmol) in methanol (50 ml), under argon, was treated with 10% Pd—C, then stirred overnight at room temperature. The mixture was filtered through a celite pad and the solvent evaporated under vacuum. The residue was dissolved in dichloromethane Na2SO4 and concentrated under vacuum to leave 230 mg of title compound as a brown oil (83% yield).

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