Hydrazine hydrate (1:1) → HCID 69127637, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1,1-dimethylethyl 4-[(4-cyano-5-methyl-2-nitrophenyl)amino]-1-piperidinecarboxylate (D91) (3 mmol) in ethanol (30 mL) was treated with Raney Nickel and hydrazine hydrate (30 mmol, 1.5 g, 10 eq) under argon at room temperature. The mixture was then heated at 45° C. for 1 h. The catalyst was then filtered off and washed with ethanol and methanol. The filtrate was concentrated under reduced pressure to give the title compound as a solid (2.55 mmol, 840 mg, 85% yield). M+H 331.3, 275.2, 231.2 (full molecule and fragments for loss of tert-butyl group and loss of Boc group).

Provenance & Evidence