Trifluoroacetic acid → HCID 69128036, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl 4-(5-cyano-6-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate (D93) (2.6 mmol, 1.15 g crude material) in dichloromethane (3 mL) was treated with trifluoroacetic acid (3 mL) under argon at room temperature and was allowed to stir for 1 h. The mixture was then concentrated under reduced pressure, the residue was treated with 10% aqueous sodium carbonate solution and extracted 3 times with ethyl acetate. The organics were combined, dried and concentrated under reduced pressure to give the title compound (2.66 mmol, 680 mg, ˜100%). M+H 257.2.

Provenance & Evidence