Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Selectfluor → 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Selectfluor | HCID 2724933 | — |
| 반응물 | 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one | HCID 77174793 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one | HCID 86618134 | — |
반응 단계
A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745646B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-1f2b2ae8e5f1496aafb24688b567536b |
| 출처 메모 | uspto-grants-2010_06 |