HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67151276, compound → 1301214-66-3
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67151276 | HCID 67151276 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1301214-66-3 | HCID 67151221 | — |
Reaction Steps
Crude 5-nitro-2-(piperidin-1-ylcarbonyl)pyridine was reduced by hydrogen under atmospheric pressure in the presence of 10% palladium on carbon (4 g) in acetic acid (500 mL). The catalyst was separated by filtration and the solvent evaporated in vacuum to give crude 6-(piperidin-1-ylcarbonyl)pyridin-3-amine, which was used for the next stage without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288405B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-27c23dd56be94dfb9f4c22ddd860dadc |
| Source note | uspto-grants-2012_10 |