HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → HCID 67151381, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | 1301214-66-3 | HCID 67151221 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 67151381 | HCID 67151381 | 23% |
Reaction Steps
A solution of sodium nitrite (69 g) in concentrated hydrochloric acid (1.5 L) was added to crude 6-(piperidin-1-ylcarbonyl)pyridin-3-amine at 0 C, and the mixture was stirred for 10 minutes. Urea (20 g) was added, and the mixture was stirred for 15 minutes. Sodium iodide (150 g) was added, and the product was separated by filtration and recrystallized from ethanol to give 5-iodo-2-(piperidin-1-ylcarbonyl)pyridine (yield 23% calculated for methyl 5-nitropyridine-2-carboxylate, 71 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288405B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-5d7cfa3f9f034f9d8d8f3bf21c39f1a2 |
| Source note | uspto-grants-2012_10 |