HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol, 2,2'-hydrazonobis- → HCID 42642474, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol, 2,2'-hydrazonobis- | HCID 26086 | — |
| Reactant | 4-Nitrophenyl (6S)-5-cyano-6-[4-cyano-2-(methylsulfonyl)phenyl]-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-1(2H)-carboxylate | HCID 66601763 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 42642474 | HCID 42642474 | — |
Reaction Steps
According to the General Procedure 1, 4-nitrophenyl (6S)-5-cyano-6-[4-cyano-2-(methylsulfonyl)phenyl]-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-3,6-dihydropyrimidine-1(2H)-carboxylate (78.0 mg, 0.125 mmol; Example 6A) was reacted with 2,2′-hydrazin-1,1-diyldiethanol (45.0 mg, 0.374 mmol) in acetonitrile (1 ml) to give the target compound (40 mg, 51% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288402B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-7b043b0a6ee54a6daf50f2f15cd96ba4 |
| Source note | uspto-grants-2012_10 |