HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-2-chlorobenzonitrile → HCID 67539870, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-2-chlorobenzonitrile | HCID 88728 | — |
| Reactant | (S)-(+)-N-(2,3-Epoxypropyl)phthalimide | HCID 719412 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 67539870 | HCID 67539870 | 43% |
Reaction Steps
According to the same procedure as Preparation Example 1, 4-cyano-3-chloroaniline (VI-d) (3.00 g, 19.66 mmol) and 2-(((S)-oxiran-2-yl)methyl)isoindoline-1,3-dione (III) (4.66 g, 20.64 mmol) were stirred under reflux in 2-propylalcohol to obtain the title compound (VII-d) (3.00 g, 8.43 mmol, 43%) as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288423B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-14dee481863b40f88345955a49458581 |
| Source note | uspto-grants-2012_10 |