Thiourea → 2-Amino-5-(4-methyl-phenyl)-thiazole-4-carboxylic acid methyl ester

HRID 2064474Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1.[NH2:16][C:17]([NH2:19])=[S:18]>>[CH3:1][O:2][C:3]([C:4]1[N:16]=[C:17]([NH2:19])[S:18][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)=[O:15]

Participants

Reactant 2

HCID 2723790Thiourea

HCID 57437153HCID 57437153, compound

Product 1

HCID 532711472-Amino-5-(4-methyl-phenyl)-thiazole-4-carboxylic acid methyl ester

Procedure

prepared by reaction of 3-chloro-2-oxo-3-p-tolyl-propionic acid methyl ester with thiourea. LC-MS: tR=0.77 min; [M+H]+=249.3.

Sources & evidence

ORD record: ord-602643fcad6c483c9a036614e0fce5e2
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288429B2

Reaction notes

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