Thiourea → Methyl 2-amino-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate

HRID 2064476Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:18])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1.[NH2:19][C:20]([NH2:22])=[S:21]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:20]([NH2:22])[S:21][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)=[O:18]

Participants

Reactant 2

HCID 2723790Thiourea

HCID 20064726HCID 20064726, compound

Product 1

HCID 53419561Methyl 2-amino-5-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate

Procedure

prepared by reaction of 3-chloro-3-(3-trifluoromethyl-phenyl)-2-oxo-propionic acid methyl ester with thiourea. LC-MS: tR=0.86 min; [M+H]+=303.3.

Sources & evidence

ORD record: ord-496ebce52b0a44c9a08980f9ba22b4ed
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288429B2

Reaction notes

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