HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → N'-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-N,N-dimethylmethanimidamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Buthidazolamine | HCID 170170 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N'-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-N,N-dimethylmethanimidamide | HCID 9583081 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 5-tert-butyl-1,3,4-thiadiazol-2-amine (Aldrich) (10.0 g, 63.6 mmol) and 1,1-dimethoxy-N,N-dimethylmethanamine (26.3 mL, 197 mmol) in 200 mL of toluene was heated at 100° C. for 12 hours. The mixture was cooled to room temperature and hexane was added. The solid was collected by filtration (hexane wash) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288428B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ff6fb80ab8f4477c83520c266296fad8 |
| Source note | uspto-grants-2012_10 |