HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 131729988, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 5-triethylsilylpent-4-yn-1-ol | HCID 2760695 | — |
| Reactant | Triphenylphosphane diiodide | HCID 21889549 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 131729988 | HCID 131729988 | — |
Reaction Steps
A solution of 5-(triethylsilyl)-4-pentin-1-ol (416 g, 2.1 mmol) in absolute acetonitrile (20 mL was added in drops to a solution of triphenylphosphine diiodide (2.80 g, 5.4 mmol) and imidazole (1.04 g, 15.4 mmol) with argon and stirred overnight at room temperature. The raw product was purified by means of flash chromatography (38 g, 20×2.5 cm) with cyclohexane/ethyl acetate (9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08288430B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3a0044242561460dbe2f9bc1d6c73c3c |
| Source note | uspto-grants-2012_10 |