3,4-dihydro-2H-pyran → HCID 10444152, compound

Participants

Reaction Steps

A solution of (S)-3-bromo-2-methylpropan-1-ol (7.30 g, 5 mL, 47.7 mmol) in anhydrous dichloromethane (100 mL) was mixed with 3,4-dihydro-2H-pyrane (4.63 g, 5.02 mL, 55 mmol) and pyridinium tosylate (50 mg) with ice cooling and then stirred for 1 h at room temperature. The reaction mixture was then washed with 5% sodium hydrogencarbonate solution and water (3×30 mL each). The combined organic phases were dried with sodium sulphate and concentrated to low volume in a vacuum.

Provenance & Evidence