Hydrochloric Acid → HCID 42634449, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve the compound obtained in Step D (4.38×10−4 mol) in dioxane (25 ml). Place under stirring and then add 37% hydrochloric acid (3.5 ml) and heat at 70° C. After 2 hours, the reaction mixture is poured into water (50 ml). Extract 3 times with ethyl acetate (20 ml). The organic phase is washed with water and then with brine, dried over magnesium sulphate, filtered and concentrated using a rotary evaporator. The oily orange-coloured crude product obtained is chromatographed on a silica column using as eluant a 60/40 n-heptane/ethyl acetate mixture.

Provenance & Evidence